Sf3b1 Cancer

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Mutations in this gene have been recurrently seen in cases of advanced chronic lymphocytic leukemia, [12] myelodysplastic syndromes [13] and breast cancer . [14] SF3B1 mutations are found in 60%-80% of patients with refractory anemia with ring sideroblasts (RARS; which is a myelodysplastic syndrome) or RARS with thrombocytosis (RARS-T; which is a myelodysplastic syndrome/myeloproliferative neoplasm). There is also an emerging body of evidence to suggest implications of SF3B1 mutations being involved in orbital melanoma.