Lynch Syndrome Medscape

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Hereditary nonpolyposis colorectal cancer ( HNPCC ) or Lynch syndrome is an autosomal dominant genetic condition that is associated with a high risk of colon cancer [1] as well as other cancers including endometrial cancer (second most common), ovary , stomach , small intestine , hepatobiliary tract , upper urinary tract , brain , and skin . The increased risk for these cancers is due to inherited mutations that impair DNA mismatch repair . It is a type of cancer syndrome .